Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.
S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.
Supplementing with SAMe
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.
SAMe and Joint Function
SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.*
SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.*
SAMe and Liver Function
SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.*
Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
Directions: Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet.
Supplement Facts
Serving Size: 1 Tablet
Serving per container: 30 servings
Amount Per Serving %DV:
S-Adenosyl Methionine 400 mg
(from 800 mg of SAM-e tosylate disulfate)
Other Ingredients: Cellulose gel, methacrylic acid copolymer, compritol 888ATO, talc, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silica, medium chain triglycerides, sodium starch glycolate, and iron oxide.
Contains nothing other than listed ingredients.
The information provided is for educational purposes only and is not intended to replace professional medical advice. Always consult with a qualified healthcare provider for personalized medical guidance.
Ingredients in SAM-e 400 (Double Strength)
- S-Adenosyl-Methionine (SAM-e)
- Cellulose
- Mannitol
- Glycerol Behenate
- Hydroxypropyl Methylcellulose Phthalate
- Acid-Resistant Enteric Coating
- Stearic Acid
- Hydroxypropyl Cellulose
- Triethyl Citrate
- Titanium Dioxide
- Magnesium Silicate
- Medium Chain Triglycerides
- Oleic Acid
- Silicon Dioxide
- Magnesium Hydroxide
- Glycerin
- Sodium Alginate
- Medium Chain Triglycerides
- Oleic Acid
- Hydroxypropyl Methylcellulose
- Modified Cellulose Gum
- Modified Cellulose
- Sodium Starch Glycolate
- Titanium Dioxide
- Iron Oxide
- Stearic Acid
- Ammonium Hydroxide
- Methacrylic Acid Copolymer
- Triethyl Citrate
The information provided is for educational purposes only and is not intended to replace professional medical advice. Always consult with a qualified healthcare provider for personalized medical guidance.
Health Benefits of SAM-e 400 (Double Strength) x 6 Bottles
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Supports Joint Health:
SAM-e is known to support joint health by promoting the production of proteoglycans, which are essential for maintaining healthy cartilage and joint function.
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Improves Mood and Emotional Well-being:
Research suggests that SAM-e may help improve mood and emotional well-being by supporting the production of neurotransmitters like serotonin and dopamine.
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Supports Liver Health:
SAM-e plays a role in supporting liver health by aiding in the production of glutathione, a powerful antioxidant that helps protect liver cells from damage.
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Boosts Cognitive Function:
Some studies have shown that SAM-e may have a positive impact on cognitive function and may help support overall brain health.
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May Help with Depression:
There is evidence to suggest that SAM-e may be beneficial in the treatment of depression, either alone or in combination with other therapies.
The information provided is for educational purposes only and is not intended to replace professional medical advice. Always consult with a qualified healthcare provider for personalized medical guidance.
Recommended Dosage:
- Start with a lower dosage and gradually increase as needed, as SAM-e can vary in effectiveness from person to person.
- The typical recommended dosage of SAM-e is 400-800mg per day, taken in divided doses.
- Consult with a healthcare provider before starting SAM-e supplementation to determine the appropriate dosage for your specific needs.
Best Practices for Usage:
- Take SAM-e on an empty stomach for optimal absorption, typically 30 minutes to 1 hour before meals.
- Do not exceed the recommended dosage unless advised by a healthcare professional.
- Consistency is key - take SAM-e regularly as part of your daily routine to experience the full benefits.
Potential Benefits of SAM-e:
- Supports joint health and may help reduce inflammation.
- May improve mood and support mental well-being.
- Supports liver health and detoxification processes.
- May help support cognitive function and brain health.
The information provided is for educational purposes only and is not intended to replace professional medical advice. Always consult with a qualified healthcare provider for personalized medical guidance.
Comparison of SAM-e 400 (Double Strength) with Similar Products:
-
SAM-e 400 (Double Strength)
- Dosage: 400mg per tablet
- Purity: High purity, pharmaceutical grade
- Quality: Double strength formula for enhanced effectiveness
- Manufacturer: Nature Made, a reputable and well-known brand in the supplement industry
-
Product A
- Dosage: 200mg per tablet
- Purity: Not specified
- Quality: Standard strength formula
- Manufacturer: Unknown
-
Product B
- Dosage: 400mg per tablet
- Purity: High purity, but not pharmaceutical grade
- Quality: Similar strength to SAM-e 400
- Manufacturer: Lesser-known brand
-
Product C
- Dosage: 500mg per tablet
- Purity: High purity, pharmaceutical grade
- Quality: Higher strength formula
- Manufacturer: Well-established brand in the supplement industry
The information provided is for educational purposes only and is not intended to replace professional medical advice. Always consult with a qualified healthcare provider for personalized medical guidance.
Alternative to SAM-e 400 (Double Strength) x 6 Bottles
While SAM-e is a popular supplement known for its potential benefits in supporting mood and joint health, there are other alternatives available that may offer similar effects. One such alternative is 5-HTP (5-Hydroxytryptophan).
5-HTP
5-HTP is a naturally occurring amino acid and chemical precursor to serotonin, a neurotransmitter that plays a key role in regulating mood, sleep, and appetite. It is commonly used as a supplement to support mental well-being and emotional balance.
According to the maker of SAM-e 400, 5-HTP may be a suitable alternative for individuals seeking mood support. It is important to note that while both SAM-e and 5-HTP can have positive effects on mood, they work through different mechanisms in the body.
Before considering any new supplement, it is recommended to consult with a healthcare provider or a qualified nutritionist to determine the most appropriate option based on individual health needs and goals.
The information provided is for educational purposes only and is not intended to replace professional medical advice. Always consult with a qualified healthcare provider for personalized medical guidance.
Alternative to SAM-e 400 (Double Strength)
When considering an alternative to SAM-e 400 (Double Strength), it is important to look for a product that offers similar benefits. One such alternative is Ademetionine.
Ademetionine (SAMe)
Ademetionine, also known as SAMe, is a naturally occurring compound found in the body that plays a crucial role in various biochemical processes. Similar to SAM-e 400, Ademetionine is known for its potential benefits in supporting mood, joint health, and liver function.
Ademetionine supplements are available in various strengths and formulations, so it is essential to consult with a healthcare provider or a nutritionist to determine the most suitable option based on individual needs and health conditions.
One reputable source for Ademetionine supplements is WebMD, which provides information on the uses, benefits, and potential side effects of Ademetionine.
Before starting any new supplement regimen, it is recommended to seek advice from a healthcare professional to ensure safety and efficacy.
The information provided is for educational purposes only and is not intended to replace professional medical advice. Always consult with a qualified healthcare provider for personalized medical guidance.
