Periwinkle contains a compound that has been shown to reduce symptoms in people whose tinnitus is due to poor blood flow. Lesser periwinkle (Vinca minor) contains a compound known as vincamine. Extracts containing vincamine have been used in Germany to help decrease tinnitus. Preliminary clinical trial data show that vinpocetine, a semi-synthetic version of vincamine, can help reduce symptoms in people whose tinnitus is due to poor blood flow.

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Periwinke’s active constitent vinpocetine has been associated with beneficial effects on hearing loss due to aging (presbyacusis), tinnitus, and ethyl-apovincaminate (a vinca alkaloid) may reduce ringing in the ears (tinnitus).